Regenerative Dental Treatments in Development

"Nanostructured Assemblies for Dental Application"

May 27, 2010 - In the June issue of the journal ACS Nano, “Nanostructured Assemblies for Dental Application,” scientists describe a first-of-its-kind, nano-sized dental film that shows early promise for regenerating pulp tissue to revitalize diseased and injured teeth.

Currently, root canal procedures help prevent tooth loss in millions of people each year.  Nadia Benkirane-Jessel and her colleagues' study introduces a new modality in regenerative endodontics, which may enable dentists to replace diseased tissue with healthy pulp tissue.  Their research study uses nanostructured multilayered films containing an anti-inflammatory agent as a new biomaterial for endodontic regeneration.  

Another application of the nanostructured films involves placing melanocyte-stimulating hormone (MSH) next to a cavity, to enable cells inside the teeth to regenerate.  For the research, also published in ACS Nano, French scientists applied the film or gel (both of which contained MSH) to mice teeth that already had cavities. One month later, the cavities were gone.  Clinical trials will likely continue for several years before the breakthrough films become available.  

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